The condition is characterized by insulin resistance, in which insulin-producing beta cells in the pancreas are unable to function effectively.
According to senior author Dr. Lorraine Gudas - chairman of the Department of Pharmacology at Weill Cornell - and colleagues, vitamin A boosts beta cell activity, meaning lack of the vitamin may play a role in the development of type 2 diabetes.
Removal of dietary vitamin A led to beta cell loss in adult miceTo find out, the team analyzed the beta cell development among two groups of adult mice; one group of mice had been genetically modified to be unable to store dietary vitamin A, while the other group was able to store the vitamin from foods as normal.
The researchers found that the mice unable to store vitamin A experienced beta cell death, meaning these mice were unable to produce insulin.
What is more, when the researchers removed vitamin A from the diets of healthy mice, they found this led to significant beta cell loss, resulting in reduced insulin production and increased blood glucose levels - key factors involved in development of type 2 diabetes. When the researchers restored vitamin A to the rodents' diets, beta cell production rose, insulin production increased and blood glucose levels returned to normal.
The researchers say their findings indicate that vitamin A deficiency may be involved in the development of type 2 diabetes. Dr. Gudas says:
"How the removal of vitamin A causes the death of the beta cells that make insulin in the pancreas is an important question we want to answer.
These beta cells in the pancreas are exquisitely sensitive to the dietary removal of vitamin A. No one has found that before. Our study sets the platform to take these studies further into preclinical and clinical settings."
The team says their findings also suggest a synthetic form of vitamin A may have the potential to reverse type 2 diabetes - something they plan to address in future research.
Symptoms
People with type 2 diabetes often have no symptoms at first. They may not have symptoms for many years.
Early symptoms of diabetes may include:
Bladder, kidney, skin, or other infections that are more frequent or heal slowly
Fatigue
Hunger
Increased thirst
Increased urination
The first symptom may also be:
Blurred vision
Erectile dysfunction
Pain or numbness in the feet or hands
Solution
Trévo provides your body with essential vitamins and minerals, vital trace minerals, amino acids, essential fatty acids, powerful antioxidants, digestive enzymes and Co-Enzyme Q10.
The sources of these life-giving nutrients come from around the world and include phytonutrients from familiar garden fruits as well as exotic fruits, green superfoods, garden vegetables, sea vegetables, herbs, and coral calcium complex. And to really supercharge the nutritional benefits of each ingredient, we have added fulvic acid, which is an amazing electrolyte that actually supercharges all the nutrients in Trévo.
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